World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Deletion of Mesenchymal Glucocorticoid Receptor Attenuates Embryonic Lung Development and Abdominal Wall Closure, Volume 8

By Shi, Wei

Click here to view

Book Id: WPLBN0003946348
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Deletion of Mesenchymal Glucocorticoid Receptor Attenuates Embryonic Lung Development and Abdominal Wall Closure, Volume 8  
Author: Shi, Wei
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Shi, W. (n.d.). Plos One : Deletion of Mesenchymal Glucocorticoid Receptor Attenuates Embryonic Lung Development and Abdominal Wall Closure, Volume 8. Retrieved from http://www.ebooklibrary.org/


Description
Description : As a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors, the glucocorticoid receptor (GR) is essential for normal embryonic development. To date, the role of mesenchymal glucocorticoid signaling during development has not been fully elucidated. In the present study, we investigated the role of the GR during embryogenesis specifically in mesenchymal tissues. To this aim, we crossed GRflox mice with Dermo1-Cre mice to generate GRDermo1 mice, where the GR gene was deleted within mesenchymal cells. Compared to their wild type littermates, GRDermo1 mice displayed severe pulmonary atelectasis, defects in abdominal wall formation resulting in intestinal herniation, abnormal extracellular matrix synthesis in connective tissues and high postnatal lethality. Lungs of GRDermo1 mice failed to progress from the canalicular to saccular stage, as evidenced by the presence of immature air sacs, thickened interstitial mesenchyme and an underdeveloped vascular network between E17.5 and E18.5. Furthermore, myofibroblasts and vascular smooth muscle cells, although present in normal numbers in GRDermo1 animals, were characterized by significantly reduced elastin synthesis, whilst epithelial lining cells of the immature saccules were poorly differentiated. A marked reduction in normal elastin and collagen deposits were also observed in connective tissues adjacent to the umbilical hernia. This study demonstrates that eliminating the GR in cells of the mesenchymal lineage results in marked effects on interstitial fibroblast function, including a significant decrease in elastin synthesis. This results in lung atelectasis and postnatal lethality, as well as additional and hitherto unrecognized developmental defects in abdominal wall formation. In addition, altered glucocorticoid signaling in the mesenchyme attenuates normal lung epithelial differentiation.

 

Click To View

Additional Books


  • Plos One : Temporo-spectral Imaging of I... (by )
  • Plos One : Effects of Mild Cold Shock 25... (by )
  • Plos One : a Personalized Best ; Charact... (by )
  • Plos One : Pre-saccadic Shifts of Visual... (by )
  • Plos One : Identification of a Nonstruct... (by )
  • Plos One : Longitudinal Liver Stiffness ... (by )
  • Plos One : Mechanical Overstimulation of... (by )
  • Plos One : Synchronous Symmetry Breaking... (by )
  • Plos One : In-depth Analysis of Patient-... (by )
  • Plos One : Unconsciously Triggered Emoti... (by )
  • Plos One : Zoledronic Acid Sensitizes Re... (by )
  • Plos One : a Lattice Model for Influenza... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.