World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Human Brain Activity Patterns Beyond the Isoelectric Line of Extreme Deep Coma, Volume 8

By Dickson, Clayton T.

Click here to view

Book Id: WPLBN0003949741
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Human Brain Activity Patterns Beyond the Isoelectric Line of Extreme Deep Coma, Volume 8  
Author: Dickson, Clayton T.
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos


APA MLA Chicago

Dickson, C. T. (n.d.). Plos One : Human Brain Activity Patterns Beyond the Isoelectric Line of Extreme Deep Coma, Volume 8. Retrieved from

Description : The electroencephalogram (EEG) reflects brain electrical activity. A flat (isoelectric) EEG, which is usually recorded during very deep coma, is considered to be a turning point between a living brain and a deceased brain. Therefore the isoelectric EEG constitutes, together with evidence of irreversible structural brain damage, one of the criteria for the assessment of brain death. In this study we use EEG recordings for humans on the one hand, and on the other hand double simultaneous intracellular recordings in the cortex and hippocampus, combined with EEG, in cats. They serve to demonstrate that a novel brain phenomenon is observable in both humans and animals during coma that is deeper than the one reflected by the isoelectric EEG, and that this state is characterized by brain activity generated within the hippocampal formation. This new state was induced either by medication applied to postanoxic coma (in human) or by application of high doses of anesthesia (isoflurane in animals) leading to an EEG activity of quasi-rhythmic sharp waves which henceforth we propose to call n-complexes (Nu-complexes). Using simultaneous intracellular recordings in vivo in the cortex and hippocampus (especially in the CA3 region) we demonstrate that n-complexes arise in the hippocampus and are subsequently transmitted to the cortex. The genesis of a hippocampal n-complex depends upon another hippocampal activity, known as ripple activity, which is not overtly detectable at the cortical level. Based on our observations, we propose a scenario of how selfoscillations in hippocampal neurons can lead to a whole brain phenomenon during coma.


Click To View

Additional Books

  • Plos One : Inferring Epitopes of a Polym... (by )
  • Plos One : Endovascular Treatment of Int... (by )
  • Plos One : Tgfa and Irf6 Contribute to t... (by )
  • Plos One : Reciprocity on the Hardwood ;... (by )
  • Plos One : European Phaseolus Coccineus ... (by )
  • Plos One : Development of Foreign Mammar... (by )
  • Plos One : Spatiotemporal Movement Plann... (by )
  • Plos One : Insights from Characterizing ... (by )
  • Plos One : Hematopoietic Stem, Volume 7 (by )
  • Plos One : Functional Interaction of Coc... (by )
  • Plos One : Novel Tumor Suppressor Functi... (by )
  • Plos One : Ocean Acidification Affects R... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.