World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Kindlin 2 Regulates Myogenic Related Factor Myogenin Viaa Canonical Wnt Signaling in Myogenic Differentiation, Volume 8

By Zhou, Zhongjun

Click here to view

Book Id: WPLBN0003951166
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Kindlin 2 Regulates Myogenic Related Factor Myogenin Viaa Canonical Wnt Signaling in Myogenic Differentiation, Volume 8  
Author: Zhou, Zhongjun
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Zhou, Z. (n.d.). Plos One : Kindlin 2 Regulates Myogenic Related Factor Myogenin Viaa Canonical Wnt Signaling in Myogenic Differentiation, Volume 8. Retrieved from http://www.ebooklibrary.org/


Description
Description : Kindlin 2, as an integrin-associated protein, is required for myocyte elongation and fusion. However, the association of Kindlin 2 with muscle differentiation-related signaling pathways is unknown. Here, we identified a mechanism that Kindlin 2 regulates myogenic regulatory factors myogenin via a canonical Wnt/b-catenin signaling. We found that knockdown of Kindlin 2 leads to the abolishment of b-catenin/TCF4-mediated transcription in C2C12 cells, followed by the impairment of myogenic differentiation. Mechanistically, nuclear translocation of both Kindlin 2 and b-catenin is induced during myogenic differentiation. In particular, Kindlin 2 forms a tripartite complex with active b-catenin and TCF4, and hence co-occupied on the promoter of myogenin to enhance its expression. Functionally, depletion of Kindlin 2 impairs myogenic differentiation via downregulation of myogenin. Taken together, our data reveal that Kindlin 2 is required for Wnt signaling-regulated myogenic differentiation, providing a mechanistic insight into the role of Kindlin-2 in muscle development.

 

Click To View

Additional Books


  • Plos One : Economic and Environmental Im... (by )
  • Plos One : Ascl1 Mash1 Knockout Perturbs... (by )
  • Plos One : Prospective Surveillance for ... (by )
  • Plos One : Identification of Genes for C... (by )
  • Plos One : Carbon Stocks of Tropical Coa... (by )
  • Plos One : Sil-tal1 Rearrangement is Rel... (by )
  • Plos One : K+ Efflux and Retention in Re... (by )
  • Plos One : Novel Frem1-related Mouse Phe... (by )
  • Plos One : the Impact of Syphilis Screen... (by )
  • Plos One : Intelligently Targeted Drug D... (by )
  • Plos One : Motor Planning in Chronic Upp... (by )
  • Plos One : Assessing Methods for Assigni... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.