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Plos Pathogens : Gogb is an Anti-inflammatory Effector That Limits Tissue Damage During Salmonella Infection Through Interaction with Human Fbxo22 and Skp1, Volume No. 8

By Schneider, David S.

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Book Id: WPLBN0003953716
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Pathogens : Gogb is an Anti-inflammatory Effector That Limits Tissue Damage During Salmonella Infection Through Interaction with Human Fbxo22 and Skp1, Volume No. 8  
Author: Schneider, David S.
Volume:
Language: English
Subject: Journels, Science, Pathogens
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Pathogens
Historic
Publication Date:
Publisher: Plos

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Schneider, D. S. (n.d.). Plos Pathogens : Gogb is an Anti-inflammatory Effector That Limits Tissue Damage During Salmonella Infection Through Interaction with Human Fbxo22 and Skp1, Volume No. 8. Retrieved from http://www.ebooklibrary.org/


Description
Description : Bacterial pathogens often manipulate host immune pathways to establish acute and chronic infection. Many Gram-negative bacteria do this by secreting effector proteins through a type III secretion system that alter the host response to the pathogen. In this study, we determined that the phage-encoded GogB effector protein in Salmonella targets the host SCF E3 type ubiquitin ligase through an interaction with Skp1 and the human F-box only 22 (FBXO22) protein. Domain mapping and functional knockdown studies indicated that GogB-containing bacteria inhibited IkB degradation and NFkB activation in macrophages, which required Skp1 and a eukaryotic-like F-box motif in the C-terminal domain of GogB. GogB-deficient Salmonella were unable to limit NFkB activation, which lead to increased proinflammatory responses in infected mice accompanied by extensive tissue damage and enhanced colonization in the gut during long-term chronic infections. We conclude that GogB is an anti-inflammatory effector that helps regulate inflammation-enhanced colonization by limiting tissue damage during infection.

 

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