World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Neuromuscular Electrical Stimulation as a Method to Maximize the Beneficial Effects of Muscle Stem Cells Transplanted Into Dystrophic Skeletal Muscle, Volume 7

By Musaro, Antonio

Click here to view

Book Id: WPLBN0003957467
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Neuromuscular Electrical Stimulation as a Method to Maximize the Beneficial Effects of Muscle Stem Cells Transplanted Into Dystrophic Skeletal Muscle, Volume 7  
Author: Musaro, Antonio
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Musaro, A. (n.d.). Plos One : Neuromuscular Electrical Stimulation as a Method to Maximize the Beneficial Effects of Muscle Stem Cells Transplanted Into Dystrophic Skeletal Muscle, Volume 7. Retrieved from http://www.ebooklibrary.org/


Description
Description : Cellular therapy is a potential approach to improve the regenerative capacity of damaged or diseased skeletal muscle. However, its clinical use has often been limited by impaired donor cell survival, proliferation and differentiation following transplantation. Additionally, functional improvements after transplantation are all-too-often negligible. Because the host microenvironment plays an important role in the fate of transplanted cells, methods to modulate the microenvironment and guide donor cell behavior are warranted. The purpose of this study was to investigate whether the use of neuromuscular electrical stimulation (NMES) for 1 or 4 weeks following muscle-derived stem cell (MDSC) transplantation into dystrophic skeletal muscle can modulate the fate of donor cells and enhance their contribution to muscle regeneration and functional improvements. Animals submitted to 4 weeks of NMES after transplantation demonstrated a 2-fold increase in the number of dystrophin+ myofibers as compared to control transplanted muscles. These findings were concomitant with an increased vascularity in the MDSC+NMES group when compared to non-stimulated counterparts. Additionally, animals subjected to NMES (with or without MDSC transplantation) presented an increased maximal specific tetanic force when compared to controls. Although cell transplantation and/or the use of NMES resulted in no changes in fatigue resistance, the combination of both MDSC transplantation and NMES resulted in a faster recovery from fatigue, when compared to non-injected and non-stimulated counterparts. We conclude that NMES is a viable method to improve MDSC engraftment, enhance dystrophic muscle strength, and, in combination with MDSC transplantation, improve recovery from fatigue. These findings suggest that NMES may be a clinically-relevant adjunct approach for cell transplantation into skeletal muscle.

 

Click To View

Additional Books


  • Plos One : Molecular Epidemiology and Ph... (by )
  • Plos One : Distance to the Scaling Law ;... (by )
  • Plos One : the Response of Cerebral Cort... (by )
  • Plos One : Wengen, the Sole Tumour Necro... (by )
  • Plos One : Climate Change and Eutrophica... (by )
  • Plos One : Gestation Dependant Changes i... (by )
  • Plos One : Absence of Ancient Dna in Sub... (by )
  • Plos One : Comprehensive Human Transcrip... (by )
  • Plos One : Research on a Community-based... (by )
  • Plos One : Reciprocal Complementation of... (by )
  • Plos One : a Population-based Study of G... (by )
  • Plos One : Comparative Analysis of Patho... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.