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Plos One : Randomized, Single Blind, Controlled Trial to Evaluate the Prime-boost Strategy for Pneumococcal Vaccination in Renal Transplant Recipients, Volume 7

By Borrow, Ray

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Book Id: WPLBN0003959037
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Randomized, Single Blind, Controlled Trial to Evaluate the Prime-boost Strategy for Pneumococcal Vaccination in Renal Transplant Recipients, Volume 7  
Author: Borrow, Ray
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Borrow, R. (n.d.). Plos One : Randomized, Single Blind, Controlled Trial to Evaluate the Prime-boost Strategy for Pneumococcal Vaccination in Renal Transplant Recipients, Volume 7. Retrieved from http://www.ebooklibrary.org/


Description
Description : Renal transplant recipients are at increased risk of developing invasive pneumococcal diseases but may have poor response to the 23-valent pneumococcal polysaccharide vaccine (PPV). It may be possible to enhance immunogenicity by priming with 7-valent pneumococcal conjugate vaccine (7vPnC) and boosting with PPV 1 year later. In a randomized single-blind, controlled study, adult recipients of renal transplants received either 7nPVC or PPV followed by PPV 1 year later. The vaccine response was defined as 2-fold increase in antibody concentration from baseline and an absolute post-vaccination values $1 mg/ml. The primary endpoint was vaccine response of the primed group (7vPnC/PPV) compared with single PPV vaccination. Antibody concentrations for 10 serotypes were measured at baseline, 8 weeks after first vaccination, before second vaccination, and 8 weeks after second vaccination. Of 320 screened patients, 80 patients were randomized and 62 completed the study. Revaccination with PPV achieved no significant increase of immune response in the 7vPnC/PPV group compared with the single PPV recipients A response to at least 1 serotype was seen in 77.1% of patients who received 7vPnC and 93.1% of patients who received PPV (P = 0.046). After second vaccination response to at least 1 serotype was seen in 87.5% patients of 7vPnC/PPV group and 87.1% patients of PPV group (non significant p). The median number of serotypes eliciting a response was 3.5 (95% CI 2.5–4.5) in the 7vPnC/PPV group versus 5 (95% CI 3.9–6.1) in the PPV group (non-significant p). Immunogenicity of pneumococcal vaccination was not enhanced by the prime–boost strategy compared with vaccination with PPV alone. Administration of a single dose of PPV should continue to be the standard of care for adult recipients of renal transplants

 

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