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Plos One : Sorting Signals That Mediate Traffic of Chitin Synthase III Between the Tgn, Volume 7

By Hong, Wanjin

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Book Id: WPLBN0003960141
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Sorting Signals That Mediate Traffic of Chitin Synthase III Between the Tgn, Volume 7  
Author: Hong, Wanjin
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Hong, W. (n.d.). Plos One : Sorting Signals That Mediate Traffic of Chitin Synthase III Between the Tgn, Volume 7. Retrieved from http://www.ebooklibrary.org/


Description
Description : Traffic of the integral yeast membrane protein chitin synthase III (Chs3p) from the trans-Golgi network (TGN) to the cell surface and to and from the early endosomes (EE) requires active protein sorting decoded by a number of protein coats. Here we define overlapping signals on Chs3p responsible for sorting in both exocytic and intracellular pathways by the coats exomer and AP-1, respectively. Residues 19DEESLL24, near the N-terminal cytoplasmically-exposed domain, comprise both an exocytic di-acidic signal and an intracellular di-leucine signal. Additionally we show that the AP-3 complex is required for the intracellular retention of Chs3p. Finally, residues R374 and W391, comprise another signal responsible for an exomer-independent alternative pathway that conveys Chs3p to the cell surface. These results establish a role for active protein sorting at the trans-Golgi en route to the plasma membrane (PM) and suggest a possible mechanism to regulate protein trafficking

 

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