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Plos One : Mir-140 Suppresses Tumor Growth and Metastasis of Non-small Cell Lung Cancer by Targeting Insulin-like Growth Factor 1 Receptor, Volume 8

By Filleur, Stephanie

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Book Id: WPLBN0003963173
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Mir-140 Suppresses Tumor Growth and Metastasis of Non-small Cell Lung Cancer by Targeting Insulin-like Growth Factor 1 Receptor, Volume 8  
Author: Filleur, Stephanie
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

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Filleur, S. (n.d.). Plos One : Mir-140 Suppresses Tumor Growth and Metastasis of Non-small Cell Lung Cancer by Targeting Insulin-like Growth Factor 1 Receptor, Volume 8. Retrieved from http://www.ebooklibrary.org/


Description
Description : MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that play important roles in carcinogenesis and tumor progression. In this study, we investigated the roles and mechanisms of miR-140 in human non-small cell lung cancer (NSCLC). We found that miR-140 is significantly downregulated in NSCLC tissues and cell lines. Both gainof- function and loss-of-function studies demonstrated that miR-140 suppresses NSCLC cell proliferation, migration, and invasion in vitro. Importantly, overexpression of miR-140 effectively repressed tumor growth and metastasis in nude mouse models. Integrated analysis identified IGF1R as a direct and functional target of miR-140. Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression, while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells. Together, our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC.

 

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