World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Requirement of Retinoic Acid Receptor B for Genipin Derivative-induced Optic Nerve Regeneration in Adult Rat Retina, Volume 8

By Barnes, Steven

Click here to view

Book Id: WPLBN0003966017
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Requirement of Retinoic Acid Receptor B for Genipin Derivative-induced Optic Nerve Regeneration in Adult Rat Retina, Volume 8  
Author: Barnes, Steven
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Barnes, S. (n.d.). Plos One : Requirement of Retinoic Acid Receptor B for Genipin Derivative-induced Optic Nerve Regeneration in Adult Rat Retina, Volume 8. Retrieved from http://www.ebooklibrary.org/


Description
Description : Like other CNS neurons, mature retinal ganglion cells (RGCs) are unable to regenerate their axons after nerve injury due to a diminished intrinsic regenerative capacity. One of the reasons why they lose the capacity for axon regeneration seems to be associated with a dramatic shift in RGCs’ program of gene expression by epigenetic modulation. We recently reported that (1R)-isoPropyloxygenipin (IPRG001), a genipin derivative, has both neuroprotective and neurite outgrowth activities in murine RGC-5 retinal precursor cells. These effects were both mediated by nitric oxide (NO)/S-nitrosylation signaling. Neuritogenic activity was mediated by S-nitrosylation of histone deacetylase-2 (HDAC2), which subsequently induced retinoic acid receptor b (RARb) expression via chromatin remodeling in vitro. RARb plays important roles of neural growth and differentiation in development. However, the role of RARb expression during adult rat optic nerve regeneration is not clear. In the present study, we extended this hypothesis to examine optic nerve regeneration by IPRG001 in adult rat RGCs in vivo. We found a correlation between RARb expression and neurite outgrowth with age in the developing rat retina. Moreover, we found that IPRG001 significantly induced RARb expression in adult rat RGCs through the S-nitrosylation of HDAC2 processing mechanism. Concomitant with RARb expression, adult rat RGCs displayed a regenerative capacity for optic axons in vivo by IPRG001 treatment. These neuritogenic effects of IPRG001 were specifically suppressed by siRNA for RARb. Thus, the dual neuroprotective and neuritogenic actions of genipin via S-nitrosylation might offer a powerful therapeutic tool for the treatment of RGC degenerative disorders.

 

Click To View

Additional Books


  • Plos One : Wheat Seedling Emergence from... (by )
  • Plos One : Fate Mapping Identifies the O... (by )
  • Plos One : Dynamics of Ceramide Channels... (by )
  • Plos One : Mesoamerican Origin and Pre- ... (by )
  • Plos One : Combined Micro-pet, Volume 7 (by )
  • Plos One : Role of an Iron-dependent Tra... (by )
  • Plos One : a Reinforcing Circuit Action ... (by )
  • Plos One : a Randomized Controlled Pilot... (by )
  • Plos One : T Cells Contribute to Stroke-... (by )
  • Plos One : Screening for and Verificatio... (by )
  • Plos One : a Detailed, Hierarchical Stud... (by )
  • Plos One : Endoglin Haplo-insufficiency ... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.