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Plos Pathogens : the Regulation of Sulfur Metabolism in Mycobacterium Tuberculosis, Volume 7

By Manchester, Marianne

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Book Id: WPLBN0003963059
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Pathogens : the Regulation of Sulfur Metabolism in Mycobacterium Tuberculosis, Volume 7  
Author: Manchester, Marianne
Volume: Volume 7
Language: English
Subject: Journels, Science, Pathogens
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Pathogens
Publication Date:
Publisher: Plos


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Manchester, M. (n.d.). Plos Pathogens : the Regulation of Sulfur Metabolism in Mycobacterium Tuberculosis, Volume 7. Retrieved from

Description : Mycobacterium tuberculosis (Mtb) has evolved into a highly successful human pathogen. It deftly subverts the bactericidal mechanisms of alveolar macrophages, ultimately inducing granuloma formation and establishing long-term residence in the host. These hallmarks of Mtb infection are facilitated by the metabolic adaptation of the pathogen to its surrounding environment and the biosynthesis of molecules that mediate its interactions with host immune cells. The sulfate assimilation pathway of Mtb produces a number of sulfurcontaining metabolites with important contributions to pathogenesis and survival. This pathway is regulated by diverse environmental cues and regulatory proteins that mediate sulfur transactions in the cell. Here, we discuss the transcriptional and biochemical mechanisms of sulfur metabolism regulation in Mtb and potential small molecule regulators of the sulfate assimilation pathway that are collectively poised to aid this intracellular pathogen in its expert manipulation of the host. From this global analysis, we have identified a subset of sulfurmetabolizing enzymes that are sensitive to multiple regulatory cues and may be strong candidates for therapeutic intervention.


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